The program was originally part of the Playhouse Disney daily block intended for preschoolers. Serving as Playhouse Disney's replacement, and later on Disney Channel every Sunday night and weekdays on 7:00-7:30-8:00 in the morning.
Mini CITV is showing the series on Weekdays at 08:45.
The Walt Disney Television Animation-produced program was initially announced on March 1, 2005 by Gary Marsh, Executive Vice President, Original Programming and Production, Disney.
This is the first time the major Disney characters have appeared on television in computer-animated form (except for Donald, who appeared in CG in the Mickey Mouse Works short "Computer.don"). The characters debuted in CG form in 2003 at the Magic Kingdom theme park attraction Mickey's PhilharMagic, then in the 2004 home video Mickey's Twice Upon a Christmas. However, in this latest incarnation, Mickey's and Minnie's 3D renderings are truer to their original hand-drawn likenesses, in that their ears remain distinct perfect circles regardless of which way their heads are turned. Along with improved animation for the second season, the series is now available in HD on Disney Channel HD.
- Wayne Allwine - Mickey Mouse (2006-2009)
- Russi Taylor - Minnie Mouse and Quoodles
- Tress MacNellie - Daisy Duck, Chip, Baby Red Bird, Mrs. Claus, and Mommy Red Bird
- Bill Farmer - Goofy and Pluto
- Tony Anselmo - Donald Duck
- Dee Bradley Baker - Santa Claus, and Boo Boo Chicken
- Corey Burton - Ludwig Von Drake, and Dale
- Jim Cummings - Pete, Granny Pete, Humphrey the Bear, Sparky, and Clyde
- Will Ryan - Willie the Giant
- Frank Welker - Mr. Pettibone, Butch the Bulldog, Bella, Sheep, and Figaro the Kitten
- April Winchell - Clarabelle Cow
- Maurice LaMarche - Mortimer Mouse
- Australia: Playhouse Disney Mickey Mouse Water House & Seven Network Adventures with Mickey Mouse
- UK and Ireland Disney Channel Dojk zxg szxc
- USA Playhouse Disney, Nick and Nick Jr
- Bulgaria: BNT 1 - Приключения с Мики Маус (Adventures with Mickey Mouse)
- Finland: YLE TV2: Mikki Hiiren kerhotalo.
- France: Playhouse Disney & Disney Channel & TF1: La Maison de Mickey.
- Hong Kong: TVB Jade: 米奇老鼠妙妙屋.
- Israel: HOP! Channel: Mickey Mouse's Friends Club (מועדון החברים של מיקי מאוס).
- Japan: Disney Channel's Playhouse Disney, various broadcasting network and TOKYO MX: ミッキーマウス クラブハウス
- Poland: Disney Channel's Playhouse Disney and TVP1: Klub przyjaciół Myszki Miki
- Slovakia: Slovenská televízia: Mickey Mouseov klub II. http://www.stv.sk/relacieaz/jednotka/mickey-mouseov-klub-ii-/.
- Spain: Playhouse Disney and Television Espanola: La casa de Mickey Mouse.
- Mexico: Playhouse Disney and Canal 7 TV Azteca: La casa de Mickey Mouse.
- Greece: ET1: Mickey Mouse: Παίζω και Μαθαίνω.
- Thailand: Channel 7 :บ้านมิคกี้แสนสนุก or สโมสรมิคกี้ เมาส์